Research

shutterstock_160671770

RESEARCH

Aging science was first based on epidemiological observations of populations with higher life expectancies and/or especially low incidence levels for certain diseases. For example, it is a known fact that certain populations, on the Mediterranean diet, have very low heart disease rates, lower incidence of cancers and higher life expectancy (Willett et al 1995).

Some research has clearly established that these low incidences of heart diseases and this longevity are strongly associated with the consumption of polyphenols, in red wine, and olive oil (Queen and Tollefsbol 2010, Fernandez and Fraga 2011).

In addition to developing cutting-edge products, Idunn Technologies conducts research activities with the best academic researchers in the aging field. Our research activities are carried out with 8 specialized researchers; Dr. in biology, pharmacology, biochemistry and genetics from different Canadian universities. Our goal is to develop the best products that will help people to “Live healthier and longer”.

NATURAL MOLECULES

The best modulators of metabolic pathways of aging come from natural molecules produced by plants. Plants developed resistance mechanisms, which can be induced by environmental conditions. They must be especially resistant given that they cannot move. This means, for example, that a plant can increase its abilities to resist to UV rays if its exposure to sunlight increases. Similarly, it can produce different molecules to protect itself from the heat, insects, mould, etc. These induced molecules are produced in small quantities to stimulate the natural maintenance and repair mechanisms and help the plant survive.

It appears that these mechanisms would be similar and inducible among other living species. As such, the maintenance and repair mechanisms of a mammal that eats this plant would be stimulated. Certain plants could, therefore, produce molecules able to delay the aging process or, at the very least, increase our resistance to it (Leonov et al 2015).

graphic-3_En

 

Most of the research conducted by Idunn Technologies is based on state-of-the-art knowledge that helps to identify the plants that are most likely to contain these sought-after molecules. This is how Idunn Technologies discovered the most efficient products ever observed up to now.

shutterstock_146384399

AGING MODELS

We use research models at the frontiers of knowledge to quickly identify and demonstrate the benefits of future natural molecules :

  • Use of screening models that are most relevant, scientifically proven and supported by a large volume of scientific literature to identify the highest anti-aging potentials.
  • Use of proven models to study the various currently marketed drugs. We use these models for the specific study of certain anti-aging impacts and/or to identify therapeutic treatment potentials. For example, there are two ongoing research programs on breast and prostate cancer.
  • Use of aging animals to observe the effects of Idunn Technologies’ natural extracts on the process slowdown and/or the regression of the metabolic parameters of aging.
  • Use of a transgenic model of a human premature aging disease. At the leading edge of current scientific knowledge, this genetic model helps to study the anti-aging impacts of Idunn Technologies products more quickly.

The studies are all conducted in partnership with Canadian universities to maintain the highest level of quality for the results obtained. This process is through, typical of the pharmaceutical field, throughout the various health research phases.

See figure

graphic6

shutterstock_255667804

RESULTS AND PUBLICATIONS

Idunn Technologies identified 6 new anti-aging agents that yield the best results up to date. This important discovery led to the filing of a new family of 6 patents for anti-aging applications.

A first science research paper, whose goal it was to position our discoveries, was published in 2015 :

  • Longevity extension by phytochemicals. Leonov A, Arlia-Ciommo A, Piano A, Svistkova V, Lutchman V, Medkour Y, Titorenko VI. Molecules. 2015 Apr 13;20(4):6544-72. Review.
  • http://www.ncbi.nlm.nih.gov/pubmed/25871373

This first publication is a literature review that examines this fascinating field. Three other publications are in the works and will be published over the next year. These three publications will present :

  1. The discovery of six new anti-aging agents,
  2. The identification of underlying action mechanisms,
  3. A new approach that helps to obtain the best anti-aging results to date.

We publish our scientific results to ensure their relevance and help expand knowledge on aging.