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“This would be the most important medical intervention in the modern era, an ability to slow ageing” Dr Jay Olshansky, University of Illinois Chicago

This is a quote from a recent article in The Telegraph (29 Nov 2015). To understant why is so important and how this is possible, I propose an article of Rafael de Cabo of the Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, 2014 (de Cabo et al, Cell. 2014 Jun 19; […]

This is a quote from a recent article in The Telegraph (29 Nov 2015).

To understant why is so important and how this is possible, I propose an article of Rafael de Cabo of the Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, 2014 (de Cabo et al, Cell. 2014 Jun 19; 157(7): 1515–1526.)

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens!

The most effective interventions proposed to date converge on only a few cellular processes, in particular nutrient signaling, mitochondrial efficiency, proteostasis, and autophagy. In this paper, de Cabo and his co-worker, critically examine drugs and behaviors to which life- or healthspan-extending properties have been ascribed and discuss the underlying molecular mechanisms.

In conclusion:

The purpose of aging research is the identification of interventions that may avoid or ameliorate the ravages of time. In other words, the quest is for healthy aging, where improved longevity is coupled to a corresponding healthspan extension. Unfortunately, numerous claims about substances or behaviors predicted to hold such benefits have been proven erroneous. In recent years, however, fasting and exercise regimens, and a number of small molecules have been shown to prolong life and/or sustain health late in life in model organisms as different as yeast and monkeys. All these interventions are compatible with the concept of programmed aging and, thus, amenable to interventions aimed at modulating molecular components and pathways responsible for the aging process. Autophagy up-regulation, improved stress resistance and mitochondrial efficiency are among the cellular functions needed to hold off features associated with accelerated aging, such as free radical generation, excess caloric intake, chronic hyperglycemia, and fat accumulation.

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